Work is a significant contributor to subjective well-being (SWB) among working people and their families. Chronic, structural work conditions and discrete emotionally-charged events have potential to influence SWB via job satisfaction, affective states experienced at work, and spillover of work into family life. In this chapter we review cumulative empirical findings on the relationship between SWB and a) characteristics of the work that people perform, b) social support and leadership at work, c) fairness and mistreatment at work, d) perceived characteristics of one’s employing organization, and e) the work-family interface. Also considered are emerging research questions about the dynamics and causal directions among work and SWB, the integration of and recovery from work and other life roles (eg, family), empirical findings taking a global perspective on work and SWB, and the role of precarious employment arrangements and unemployment in worker SWB. Empirical results indicate that factors from each of these areas correlate with SWB, although some are more predictive than others, and results vary across dimensions of SWB. Furthermore, questions remain about causal relationships and temporal dynamics among work and SWB and differences across cultures and regions of the world. As science continues to accumulate on SWB, the role of work will continue to be better understood alongside other life factors.